abstract：:The Drosophila ovary offers a suitable model system to study the mechanisms that orchestrate diverse cellular processes. Oogenesis starts from asymmetric stem cell division, proper differentiation and the production of fully patterned oocytes equipped with all the maternal information required for embryogenesis. Spati...

journal_title：Cells

authors： Antel M,Inaba M

更新日期：2020-01-22 00:00:00

abstract：:Disseminated metastatic cancer cells represent one of the most relevant causes of disease relapse and associated death for cancer patients, and a therapeutic target of the highest priority. Still, our understanding of how disseminated cancer cells survive in the foreign metastatic environment, and eventually cause met...

journal_title：Cells

authors： Montagner M,Dupont S

更新日期：2020-01-19 00:00:00

abstract：:Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWA...

journal_title：Cells

authors： Golov AK,Kondratyev NV,Kostyuk GP,Golimbet AVE

更新日期：2020-01-18 00:00:00

abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...

journal_title：Cells

authors： Kim YH,Cho KA,Lee HJ,Park M,Shin SJ,Park JW,Woo SY,Ryu KH

更新日期：2020-01-15 00:00:00

abstract：:Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at external and internal surfaces of the body where they act in the first line of defense. MCs are found in all studied vertebrates and have also been identified in tunicates, an early chordate. To obtain a detailed insight into the ...

journal_title：Cells

authors： Akula S,Paivandy A,Fu Z,Thorpe M,Pejler G,Hellman L

更新日期：2020-01-14 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate wit...

journal_title：Cells

authors： Falcón D,Galeano-Otero I,Martín-Bórnez M,Fernández-Velasco M,Gallardo-Castillo I,Rosado JA,Ordóñez A,Smani T

更新日期：2020-01-10 00:00:00

abstract：:Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...

journal_title：Cells

authors： Nouwen LV,Everts B

更新日期：2020-01-09 00:00:00

abstract：:Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell proliferation and anti-apoptotic genes in order to stimulate cel...

journal_title：Cells

authors： Miyajima C,Kawarada Y,Inoue Y,Suzuki C,Mitamura K,Morishita D,Ohoka N,Imamura T,Hayashi H

更新日期：2020-01-09 00:00:00

abstract：:Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a ma...

journal_title：Cells

authors： Negreiros-Lima GL,Lima KM,Moreira IZ,Jardim BLO,Vago JP,Galvão I,Teixeira LCR,Pinho V,Teixeira MM,Sugimoto MA,Sousa LP

更新日期：2020-01-06 00:00:00

abstract：:Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integrity of ciliary signaling, it is mandatory that the ciliary signaling p...

journal_title：Cells

authors： Tschaikner P,Enzler F,Torres-Quesada O,Aanstad P,Stefan E

更新日期：2020-01-03 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:: In this review, we summarize the current knowledge on miRNAs as therapeutic targets in two cancer types that were frequently described to be driven by miRNAs-melanoma and hepatocellular carcinoma (HCC). By focusing on common microRNAs and associated pathways in these-at first sight-dissimilar cancer types, we aim at...

journal_title：Cells

authors： Linck-Paulus L,Hellerbrand C,Bosserhoff AK,Dietrich P

更新日期：2020-01-02 00:00:00

abstract：:In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at postnatal day 2-4 (P2-4), w...

journal_title：Cells

authors： Felix L,Ziemens D,Seifert G,Rose CR

更新日期：2019-12-31 00:00:00

abstract：:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...

journal_title：Cells

authors： Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

更新日期：2019-12-28 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Cl...

journal_title：Cells

authors： Howe HS,Leung BPL

更新日期：2019-12-27 00:00:00

abstract：:Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in p...

journal_title：Cells

authors： Yun CW,Kim HJ,Lim JH,Lee SH

更新日期：2019-12-24 00:00:00

abstract：:During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...

journal_title：Cells

authors： Biamonti G,Infantino L,Gaglio D,Amato A

更新日期：2019-12-21 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...

journal_title：Cells

authors： Dewing JM,Carare RO,Lotery AJ,Ratnayaka JA

更新日期：2019-12-21 00:00:00

abstract：:Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...

journal_title：Cells

authors： Rapado-González Ó,López-López R,López-Cedrún JL,Triana-Martínez G,Muinelo-Romay L,Suárez-Cunqueiro MM

更新日期：2019-12-17 00:00:00

abstract：:Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transit...

journal_title：Cells

authors： Kiełbus M,Czapiński J,Kałafut J,Woś J,Stepulak A,Rivero-Müller A

更新日期：2019-12-15 00:00:00

abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...

journal_title：Cells

authors： Tzeng HT,Chyuan IT,Chen WY

更新日期：2019-12-13 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00

abstract：:There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...

journal_title：Cells

authors： Harrell CR,Jovicic N,Djonov V,Arsenijevic N,Volarevic V

更新日期：2019-12-11 00:00:00

abstract：:(1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved in the development of several human diseases. Intestinal cells are continuously exposed to pro-oxidants and l...

journal_title：Cells

authors： Morresi C,Cianfruglia L,Sartini D,Cecati M,Fumarola S,Emanuelli M,Armeni T,Ferretti G,Bacchetti T

更新日期：2019-12-11 00:00:00

abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...

journal_title：Cells

authors： Umair M,Alfadhel M

更新日期：2019-12-09 00:00:00

abstract：:In liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucago...

journal_title：Cells

authors： Avalos-de León CG,Jiménez-Castro MB,Cornide-Petronio ME,Casillas-Ramírez A,Peralta C

更新日期：2019-12-09 00:00:00

abstract：:(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...

journal_title：Cells

authors： Bonig H,Kuçi Z,Kuçi S,Bakhtiar S,Basu O,Bug G,Dennis M,Greil J,Barta A,Kállay KM,Lang P,Lucchini G,Pol R,Schulz A,Sykora KW,Teichert von Luettichau I,Herter-Sprie G,Ashab Uddin M,Jenkin P,Alsultan A,Buechner J,S

更新日期：2019-12-05 00:00:00

abstract：:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...

journal_title：Cells

authors： Calura E,Ciciani M,Sambugaro A,Paracchini L,Benvenuto G,Milite S,Martini P,Beltrame L,Zane F,Fruscio R,Marchette MD,Borella F,Tognon G,Ravaggi A,Katsaros D,Bignotti E,Odicino F,D'Incalci M,Marchini S,Romualdi C

更新日期：2019-12-01 00:00:00

abstract：:The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...

journal_title：Cells

authors： Bouvet M,Blondeau JP,Lezoualc'h F

更新日期：2019-11-29 00:00:00

abstract：:To identify novel oncogenic targets in head and neck squamous cell carcinoma (HNSCC), we have analyzed antitumor microRNAs (miRNAs) and their controlled molecular networks in HNSCC cells. Based on our miRNA signature in HNSCC, both strands of the miR-99a-duplex (miR-99a-5p: the guide strand, and miR-99a-3p: the passen...

journal_title：Cells

authors： Okada R,Koshizuka K,Yamada Y,Moriya S,Kikkawa N,Kinoshita T,Hanazawa T,Seki N

更新日期：2019-11-28 00:00:00

abstract：:Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a l...

journal_title：Cells

authors： Samak M,Hinkel R

更新日期：2019-11-27 00:00:00

abstract：:Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...

journal_title：Cells

authors： Barrault L,Gide J,Qing T,Lesueur L,Tost J,Denis JA,Cailleret M,Aubry L,Peschanski M,Martinat C,Baghdoyan S

更新日期：2019-11-26 00:00:00

abstract：:Insulin and insulin-like growth factor-1 (IGF1) have important roles in breast cancer development. The recent identification of nuclear insulin (INSR) and IGF1 (IGF1R) receptors provides a novel paradigm in the area of signal transduction. The fact that INSR and IGF1R can function as transcription factors, capable of ...

journal_title：Cells

authors： Sarfstein R,Nagaraj K,LeRoith D,Werner H

更新日期：2019-11-23 00:00:00

abstract：:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeos...

journal_title：Cells

authors： Trstenjak Prebanda M,Završnik J,Turk B,Kopitar Jerala N

更新日期：2019-11-21 00:00:00

abstract：:Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly rea...

journal_title：Cells

authors： Rodríguez C,Martínez-González J

更新日期：2019-11-21 00:00:00

abstract：:Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tumor hypoxia up to true anoxia. Recent reports have shown that m...

journal_title：Cells

authors： Gammon ST,Pisaneschi F,Bandi ML,Smith MG,Sun Y,Rao Y,Muller F,Wong F,De Groot J,Ackroyd J,Mawlawi O,Davies MA,Gopal YNV,Di Francesco ME,Marszalek JR,Dewhirst M,Piwnica-Worms D

更新日期：2019-11-21 00:00:00

abstract：:Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study...

journal_title：Cells

authors： Shi CS,Kuo KL,Chen MS,Chow PM,Liu SH,Chang YW,Lin WC,Liao SM,Hsu CH,Hsu FS,Chang HC,Huang KH

更新日期：2019-11-19 00:00:00

abstract：:Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the reg...

journal_title：Cells

authors： Ferko M,Andelová N,Szeiffová Bačová B,Jašová M

更新日期：2019-11-17 00:00:00